MRI Clinical Faculty

Evanthia Bernitsas, MD
Associate Professor of Neurology
Wayne State University School of Medicine
Director of the Multiple Sclerosis Center
Email: ebernits@med.wayne.edu

Publications: link

Research interests: I study the application of multimodal imaging in the pathophysiology, diagnosis and therapeutics of multiple sclerosis and related demyelinating disorders. My research interests focus on the correlation between imaging and clinical outcomes, detection of early changes, and association of these changes with clinical metrics and disease course.
Our team uses advanced imaging technology to investigate gray and white matter pathology, the effect of disease modifying agents on the CNS and the potential mechanisms for remyelination. My goal is to use imaging biomarkers for an accurate diagnosis and successful therapeutic interventions.

Csaba Juhasz, MD, PhD
Professor of Pediatrics, Neurology, Neurosurgery
Wayne State University School of Medicine
Email: csaba.juhasz@wayne.edu

Publications: link

Research interests: My overall goal is to combine my clinical and research background with my expertise in multimodal imaging to find better ways to diagnose and treat patients with various neurological disorders, with the main focus on epilepsy, brain tumors, and Sturge-Weber syndrome (SWS). Our group pioneered the use of novel PET tracers in localization of epileptic foci, including imaging GABA receptors, tryptophan metabolism, and activated microglia. I have also introduced the clinical use of tryptophan PET in the imaging of human brain tumors.
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Another major line of my clinical research is the longitudinal, multimodal imaging of SWS that yielded one of the largest MRI and PET databases of children with SWS, collected since 2003. I also study advanced MRI and PET approaches to study epileptic foci in children who undergo epilepsy surgery. I have active collaborations with several research groups at WSU as well as in other U.S. institutes, including Northwestern University, Kennedy Krieger Institute/Johns Hopkins University, Boston Children's Hospital/Harvard University, the University of Illinois, as well as the Sturge-Weber Foundation and participants of the Brain Vascular Malformation Consortium.

Jun Li, MD, PhD
Professor and Chair of Neurology
Wayne State University School of Medicine
Email: junli@med.wayne.edu

Publications: link

Research interests: Dr. Jun Li's research has two arms – basic science in his laboratory (Research Lab website) and clinical research. Research in our lab is focused on acquiring a better understanding of Schwann cell biology and inherited peripheral nervous diseases. Clinical presentation of patients with inherited peripheral nerve diseases typically includes distal muscle weakness, sensory loss, foot deformities and absent deep tendon reflexes.
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Currently, there are over 90 specific genes that are linked with different subtypes of CMT. However, over 20% of diagnosed inherited neuropathies still have no known genetic cause. We investigate how myelinating Schwann cells interact with axons and how genetic mutations in various types of inherited peripheral neuropathies - also known as Charcot-Marie-Tooth diseases (CMT) - alter the molecular signaling between the two types of cells. We hope that these investigations will lead to molecular targets for developing therapeutic interventions. We are studying those diseases using a variety of in vitro and in vivo models in our lab.
With respect to our clinical studies, Dr. Jun Li directs a CMT clinic that is specifically designated to the patients with inherited neuropathies. This multi-disciplinary clinic occurs weekly at University Health Center. We are a part of the NIH funded Rare Disease Clinical Research Network - Inherited Neuropathies Consortium. We are interested in genotype/phenotype correlation, identification of novel genes causing CMT, and use of human skin biopsy as a minimally invasive tool in evaluation of peripheral pathology. In addition, we have been collaborating with the MR Research Facility to develop non-invasive imaging biomarkers for peripheral nerve diseases.

Swathi Mody, MD
Assistant Professor, Department of Radiology
Director of Pediatric Neuroradiology and Fetal Imaging
Wayne State University School of Medicine
Email: smody@med.wayne.edu

Publications: link

Research interests: With my clinical background in pediatric radiology and neuroradiology, my main research interest are in fetal and neonatal neuroimaging and imaging of the placenta.

David R. Rosenberg, MD
Professor and Chair of Psychiatry
Department of Psychiatry and Behavioral Neurosciences
Wayne State University School of Medicine
Email: drosen@med.wayne.edu

Publications: link

Research interests: My main research interest has been the identification of neurobiological markers of pediatric obsessive-compulsive disorder (OCD) and related disorders. Specific research interests have included the examination of glutamate, neurochemical, functional, and structural abnormalities in pediatric OCD and obsessive-compulsive behaviors (OCB) using volumetric and functional MRI, voxel based morphometry and magnetic resonance spectroscopy and most recently combining these brain imaging methods with genetic assessment. The goal of my research is to provide a better understanding of the impact of genetic variants on fronto-striatal-thalamocortical and glutamatergic dysregulation in the pathogenesis of OCD and OCB and lead to new diagnostic, therapeutic, and prevention strategies.

Imad Zak, MD
Professor of Radiology
Chief of Neuroradiology & Clinical Director of MRI
Wayne State University School of Medicine
Email: izak@wayne.edu

Publications: link

Research interests: Multiple sclerosis, imaging and clinical trials
CSF flow dynamics in multiple sclerosis as compared to leukoariaosis (chronic ischemic demylination)