Wayne State University

Aim Higher

Molecular Imaging

Title: Study of Advanced Eu(II)-Based Contrast Agents for Ultra-High Field Magnetic Resonance Imaging

PI Name: Dr. Matt J Allen,
Professor and Chair of Chemistry
Department of Chemistry
Wayne State University

Personal website: chem.wayne.edu/allengroup


Sagittal MRI can be used to noninvasively visualize the inside of living organisms. This property of MRI has greatly advanced the ability to diagnose disease and evaluate medical conditions. Lanthanide complexes can enhance inherent contrast in MR images through interactions with solvent molecules.
MRI can be used to noninvasively visualize the inside of living organisms. This property of MRI has greatly advanced the ability to diagnose disease and evaluate medical conditions. Lanthanide complexes can enhance inherent contrast in MR images through interactions with solvent molecules. Through the selective enhancement of contrast, MRI can be converted into an even more powerful tool for imaging biological events on the molecular level (molecular imaging); however, there are major limitations to the use of existing rare earth complexes in improving the diagnostic capabilities of MRI and in the study of complicated biological systems. To overcome these limitations, our laboratory uses novel coordination chemistry to manipulate the properties of lanthanide ions. Specifically, we are interested in controlling the magnetic and electronic interactions of lanthanide ions with their surrounding environment and in stabilizing unstable oxidation states. These projects will illuminate fundamental properties of lanthanides. Additionally, they are an inroad toward greatly enhancing the molecular imaging and diagnostic capabilities of MRI.

List of research focus titles: new contrast agents, oxygen sensing by MRI

Publications:
  1. Basal, L. A.; Yan, Y.; Shen, Y.; Haacke, E. M.; Mehrmohammadi, M.*; Allen, M. J.* Oxidation-Responsive, Eu(II/III)-Based, Multimodal Contrast Agents for Magnetic Resonance and Photoacoustic Imaging. ACS Omega, 2017,2, 800–805. DOI
  2. Corbin, B. A.; Basal, L. A.; White, S. A.; Shen, Y.; Haacke, E. M.; Fishbein, K. W.; Allen, M. J.* Screening of Ligands for Redox-Active Europium Using Magnetic Resonance Imaging. Bioorg. Med. Chem. in press DOI
  3. Lenora, C. U.; Carniato, F.; Shen, Y.; Latif, Z.; Haacke, E. M.; Martin, P. D.; Botta, M.*; Allen, M. J.* Structural Features of Eu(II)-Containing Cryptates That Influence Relaxivity. Chem. Eur. J. 2017,23, 15404–15414. DOI